Nucleosomics

VolitionRx is developing a range of diagnostic tests for cancer and other conditions, based on its Nucleosomics® technology.

Nucleosomics® is a platform technology to measure and identify signatures of nucleosomes circulating in the blood.

Nucleosomes of disease origin are structurally different (i.e. have different patterns of histone modification, DNA modifications, DNA methylation or certain adducts) from nucleosomes of other cells.

 

How Nucleosomics® Works

A nucleosome is a section of DNA that is wrapped around a core of proteins.

DNA is compacted as protein complexes in a “beads on a string” structure.

Nucleosome “beads” consist of DNA wrapped around a core of histone proteins.

Each core consists of four pairs of variants of H2A, H2B, H3 and H4 histones.

Histones and DNA are subject to a variety of post translational modifications.

Various proteins interact with nucleosomes to modulate gene expression.

 

VolitionRx’s Solution

VolitionRx’s tests have shown, in several trials, the ability to distinguish cancer patients from healthy patients and those with other blood nucleosome-elevating conditions, and to distinguish one type of cancer from another (prostate from colorectal cancer).