First VolitionRx Study Data Presented at CNAPS, Baltimore
Initial study results demonstrate detection rate of 75% for colorectal cancer
Dr. Stefan Holdenrieder, who coordinated the trial, is based at the Institute of Clinical Chemistry and Clinical Pharmacology at University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn. He is an expert in the field of circulating nucleosomes, and is widely published, having authored over 70 journal papers and several patents. Some example relevant publications may be found in the notes below*.
The results from the 90 patient study demonstrate that Volition’s NuQ-5mc assay was able to detect 75% of patients with colorectal cancer (CRC) at 70% specificity compared to healthy samples. The results were validated in a second set of 113 people.
“These initial results are a promising indicator that blood based methylation levels are a valuable biomarker in the diagnosis of colorectal cancer” Dr Holdenrieder commented. “The sensitivity and specificity achieved in the NuQ-5mc trial is comparable to other single-biomarker cancer diagnostic tests such as the widely adopted PSA for prostate cancer.”
“To get such encouraging results from a single assay gives us a solid platform to build on in our larger trials with multiple markers,” said Dr Jake Micallef, Chief Scientific Officer of VolitionRx. “Our approach is to combine two or more assays, which have shown differentiation independently from our current suite of 21 validated NuQ biomarkers, with the aim of significantly higher sensitivity and specificity than from single markers alone. This initial data is the first in a series of trials currently underway for colorectal cancer diagnosis. In addition to these exciting results from Bonn, we expect to be able to report on our ongoing trials in Mont Godinne (Belgium) later in the year and the completion of the first 1000 patients of our pivotal Danish study Q1 2014.”
The poster abstract and a PDF of the poster is available on VolitionRx's website at: http://volitionrx.com/technologies-abstracts-papers-posters.html
The full results and methodology of the study have been submitted for publication.
Volition is carrying out several further clinical trials on the effectiveness of the NuQ assays as a cancer diagnostic tool:
*Some of Dr Holdenrieder’s notable publications:
VolitionRx is a life sciences company focused on developing blood-based diagnostic tests for different types of cancer. The tests are based on the science of Nucleosomics which is the practice of identifying and measuring nucleosomes in the bloodstream – an indication that cancer is present.
VolitionRx’s goal is to make the tests as common and simple to use, for both patients and doctors, as existing diabetic and cholesterol blood tests. VolitionRx’s research and development activities are currently centered in Belgium as the company focuses on bringing its diagnostic products to market first in Europe, then in the US and ultimately, worldwide.
Media Contacts:Charlotte Reynolds, VolitionRx
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Laura Larsen, Racepoint Group
Telephone: +44 (0) 208 811 2128
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